Through a series of experiments, a number of researchers found that the brain produces insulin and that this substance generated by brains of individuals with Alzheimer’s illness tends to fall below normal levels.
For your neuropathologist at Rhode Island Hospital and professor of pathology at Brown University Medical School, Suzanne M. de la Monte, “insulin disappears early and dramatically in Alzheimer’s disease and many of the unexplained features of Alzheimer’s, such as cell death and tangles in the brain, appear to be linked to abnormalities in insulin signaling. This demonstrates that the disease is most likely a neuroendocrine disorder, or another sort of diabetes”.
During the first stages of Alzheimer’s disease, brain levels of insulin and its related cellular receptors fall precipitously, as her team of researchers explained. They think that Alzheimer’s may be a new form of diabetes since the evidence reveals insulin levels continue to drop progressively as the Alzheimer’s disease gets more severe.
The group led by de la Monte additionally found that low levels of acetylcholine are directly associated with this loss of insulin and insulin-like growth factor function in the brain. Acetylcholine is a hallmark of Alzheimer’s disease.
The researchers team autopsied the brain tissue of 45 patients diagnosed with different degrees of Alzheimer’s called “Braak Stages” and compared those tissues to samples taken from individuals with no history of the illness.