The study was completed using 24 volunteers who had diabetic foot ulcers but that revealed no signs of disease or flow problems in their own extremities. Some patients have been assigned to 4 weeks of daily treatment with topical 0.05 percent tretinoin alternative meanwhile the management group was assigned to a therapy using a saline solution. Both teams were evaluated every two weeks.
The 22 volunteers who finished the study have been influenced by a total of 24 foot ulcers. 18 percent of individuals in the control group (two of those 11 ulcers) and 46 percent of individuals in the treated group (6 of those 13 ulcers) attained a total recovery at the end of 16 weeks. There was no statistical importance of adverse events, although some patients experienced moderate pain in the ulcer website.
The investigators were delighted with the outcome, even though they were somewhat worried because tretinoin irritates and they believed that the patients could come to be so annoyed they would not have the ability to continue the study. But this scenario did not appear to be an issue generally, since they explained.
A decision for the investigators was that they expect that diabetic foot clinics understand about it and utilize Retin-A when other treatments that they use do not work.